The name “della Vigna” derives from a vineyard given to the Franciscans in 1253. The church, which the order built here in the 13th century, was rebuilt under Jacopo Sansovino in 1534, with a façade added in 1562-1572 by Palladio. The façade bears the following inscriptions in large bronze characters:
DEO UTRIUSQUE TEMPLI AEDIFICATORI AC REPARTORI
'To God, builder of this and the other temple. Enter this temple /do not abandon the realities of the spirit /not without the effort of detaching yourself from the burden of external things /and an internal fight. Only then will the Lord renew your life'.
The interior has a rich collection of works of art, including sculptures by Alessandro Vittoria, Paolo Veronese’s The Holy Family with Saints, and Negraponte’s Virgin and Child. The Madonna and Child with Saints by Giovanni Bellini hangs near the cloister.